Elaine breaks up with her boyfriend Kevin, but they decide to remain friends. Kevin proves to be a much more reliable friend than Jerry, leading Jerry to suggest that Kevin is "Bizarro Jerry", and explains to Elaine how the Superman character Bizarro does everything in an opposite manner to Superman.
While using the restrooms at a company called Brandt-Leland, Kramer assists an employee with a printer and is mistaken for a co-worker by the staff. He begins showing up at regular work hours with no contract and no pay, simply appreciating the structure that a steady job adds to his life.
Jerry starts dating Gillian, an attractive woman whose only flaw is that she has "man-hands", meaning her hands are large and strong like a man's. George gets into a club of attractive female models by saying that a photo of Gillian is his late fiancee Susan. He accidentally burns the picture with a hair dryer. Jerry breaks up with Gillian due to her hands. While Jerry tries to get another picture of her from her purse for George, she grabs Jerry's hand, crushing it. Jerry feels jealous and neglected at home, now that Kramer is working, Elaine is hanging out with Kevin and his friends Gene and Feldman (Bizarro versions of George and Kramer, respectively) and George refuses to bring him along to the club.
Kramer develops an ulcer from overwork. He is terminated by Leland because of his incomprehensible report; when he retorts that he does not actually work for the company, Leland replies, "That's what makes this so difficult." Kramer acknowledges that working was a mistake and agrees to spend more time with Jerry.
Jerry, George and Kramer head to the coffee shop and bump into Elaine as she is meeting up with Kevin, Gene and Feldman. Kevin and his friends are kind, considerate and very polite, as opposed to the selfish and obnoxious attitudes of Jerry, George and Kramer, prompting Elaine to stay with her "Bizarro friends". Kevin invites her over, and she meets Vargas, the Bizarro Newman, with whom Kevin is friendly. However, Kevin and his friends are bothered by her behavior, and reject her after she uses her signature "Get out!" shove on Kevin. A saddened Elaine takes her leave.
George tries to use a picture of a model from a magazine to get back into the club, but he accidentally approaches the same model from the magazine picture and is kicked out. Later, he takes Jerry to the location of the club, but all they find is a meat packing plant, with the photo George took from a magazine lying unnoticed on the dirty floor.
In a mid-credits scene, Kevin’s friends console him over the loss of Elaine. The three gather into a group hug, and a tearful Kevin declares, "Me so happy, me want to cry," imitating Bizarro Superman's distinctive speech pattern.